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. 2009 May 28;9:112. doi: 10.1186/1471-2180-9-112

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Copyright ©2009 Gristwood et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The proposed mechanism by P_ilimitation can upregulate secondary metabolism in Serratia 39006. In response to P_ilimitation (or pstS mutation), PhoR activates PhoB by phosphorylation. Active PhoB can then activate transcription of smaI, pigA and rap (indicated using solid arrows). Upregulation of smaI results in activation of the QS regulated genes (pigA, carA and rap), via AHL mediated SmaR derepression (indicated using dashed arrows). Rap then further activates carA and pigA expression (indicated using solid arrows). This results in upregulation of Pig and Car production.