TABLE 2.
FIFTEEN GENES SHOWING ADDITIONAL EVIDENCE OF ASSOCIATION WITH ASTHMA
| Gene | UCSC Location (build Mar. 2006) | Additional SNPs Tested | SNP < 0.05 | % SNP Significant | pmin | rs of pmin |
|---|---|---|---|---|---|---|
| IL10 | chr1: 205000986–205018827 | 7 | 1 | 14 | 0.01 | rs3021094 |
| CHI3L1 | chr1: 201408561–201435504 | 11 | 1 | 9 | 0.04 | rs946263 |
| NPPA | chr1: 11819241–11835780 | 4 | 2 | 50 | 0.002 | rs198372 |
| CTLA4 | chr2: 204430997–204452775 | 2 | 1 | 50 | 0.04 | rs733618 |
| DPP10 | chr2: 114909360–116350519 | 248 | 25 | 10 | 0.001 | rs1914973 |
| INPP4A | chr2: 98383407–98603871 | 14 | 1 | 7 | 0.02 | rs11676357 |
| MYLK | chr3: 124774156–125135166 | 31 | 1 | 3 | 0.04 | rs11718105 |
| PAFAH | chr6: 46731657–46824038 | 16 | 3 | 19 | 0.02 | rs974670 |
| GPR154* | chr7: 34658901–34893456 | 60 | 3 | 5 | 0.01 | rs17789834 |
| FCER1B | chr 11: 59607673–59673270 | 3 | 1 | 33 | 0.05 | rs12361312 |
| GSTP1 | chr11: 67060003–67116179 | 7 | 3 | 43 | 0.03 | rs614080 |
| IRAK-3 | chr12: 64861524–64934595 | 5 | 1 | 20 | 0.05 | rs1152912 |
| PHF11* | chr13: 48920090–49007585 | 20 | 9 | 45 | 0.01 | rs2981 |
| PTGDR | chr14: 51797382–51828230 | 5 | 1 | 20 | 0.04 | rs1953367 |
| ITGB3 | chr17: 42672021–42751086 | 17 | 1 | 6 | 0.04 | rs16969966 |
Definition of abbreviations: chr = chromosome; LD = linkage disequilibrium; pmin = lowest family-based association test P value of all SNPs tested in a gene; rs of pmin = rs number of the pmin SNP; SNP = single-nucleotide polymorphism; UCSC = University of California, Santa Cruz (UCSC) Genome Browser.
SNPs in the Illumina 550K array that were within the 39 genes and their neighboring LD-flanking region were tested for association with asthma in an additive model. All P values here are two-sided. The SNPs that were tested for association with previous asthma SNPs are not re-represented here. Underlining denotes asthma genes identified via positional cloning approaches.
SNP associations with asthma in CAMP have been previously published for these genes (28).