Table 1.

Characteristics of Included Studies

Study	Country/setting	Comorbid Condition	N	Mean Age (yrs)	Compared Interventions	Mean Dose (mg)	Treatment Length
Pharmacologic Management of Delirium
Breitbart16	USA/Medical Services	AIDS, Medical patients	30	39	Haloperidol	1.4 - 2.8	Up to 6 days
					Chlorpromazine	36 - 50
					Lorazepam	3 - 4.6
Han17	Korea/ICU and Medical Services	Medical and surgical patients	24	66	Haloperidol Risperidone	1.7	7
						1
Lee18	South Korea/Medical and Surgical services	Medical and surgical patients	31	62	Amisulpride Quetiapine	156	Up to 7 days
						113
Skrobik19	Canada/ICU	Medical and surgical patients	73	65	Haloperidol Olanzapine	6.5	5 days
						4.5
Prevention of Delirium
Liptzin20	USA/Orthopedic Surgery	Elective knee or hip surgery	80	67	Donepezil placebo	Not reported	28 days
Sampson21	UK/Orthopedic Surgery	Elective hip surgery	33	68	Donepezil placebo	5 mg daily	4 days
Kalisvaart22	Netherlands/Orthopedic Surgery	Emergent or elective hip fracture surgery	430	79	Haloperidol placebo	0.5 mg three times daily	Minimum 1 day, Maximum 6 days
Diaz23	Chile/Orthopedic Surgery	Elective or emergent hip fracture surgery	81	79	Citicoline Placebo	400 mg every 8 hours	4 days
Pandharipande24	USA/Medical and Surgical Services	Mechanically ventilated adults	106	60	Dexmedetomidine Lorazepam	0.74 mcg/hr 3 mg/hr	Up to 120 hours
Aizawa25	Japan/Surgery	Gastric or colon Resection surgery	42	76	Diazepam, Flunitrazepam, pethidine vs. placebo	0.1 mg/kg × 1 0.04 mg/kg drip 1 mg/kg drip	3 days
Prakanrattana26	Thailand/Surgery	Cardiac Surgery	126	61	Risperidone placebo	1 mg	1 day
Leung27	USA/Neurosurgery	Spine surgery	21	60	Gabapentin placebo	900 mg/day	3 days
Leung28	USA/Surgery	Non-cardiac surgery	228	74	Nitrous oxide + O2 O2	NR	Procedural administration

N: Total number of subject in the trial; USA: United States of America; AIDS: Acquired Immunodeficiency Syndrome; ICU: Intensive care unit; NR: Not Reported