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. 2009 Jun 23;4(6):e6007. doi: 10.1371/journal.pone.0006007

Figure 4. Different Requirement of BDNF Activity and Synthesis During the Two Time Windows of Memory Consolidation.

Figure 4

Data are expressed as mean (±SEM) of training (TR, black bars) or test session step-down latency at 24 h after IA training. Animals were infused intra-CA1 of the dorsal hippocampus with vehicle (Vh, white bars) or function-blocking anti-BDNF antibodies (1 µg/µl, grey bars) 15 min before (A) or 3 h (B) after training. Animals were infused intra-CA1 of the dorsal hippocampus with BDNF MSO (white bar) or BDNF ASO (2 nmol/µl, 1 µg/side, grey bar), 2 h before (C) or 1 h (D) after IA training. *p<0.05, **p<0.01, ***p<0.001 vs Vh (A, B) or MSO (C, D), n = 10 per group for each experiment.