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. 2009 Jun 23;4(6):e6007. doi: 10.1371/journal.pone.0006007

Figure 5. BDNF Triggers mTOR Activation in the Hippocampus During IA Training and 3 h Thereafter.

Figure 5

Bars represent mean p-mTOR/mTOR (A and C) or p-p70S6K/p70S6K ratio (B and D) of rats infused with vehicle (black), function-blocking anti-BDNF antibodies (0.5 µg/side; grey), respect to the naïve group (white). Intra-CA1 infusion of function-blocking anti-BDNF antibodies 15 min before IA training prevents mTOR (A) and p70S6K (B) activation immediately or 15 min after training respectively and infusion 2∶45 h after training prevents mTOR (C) and p70S6K (D) activation 3 h after training. Representative blots of phosphorylated and total protein levels of mTOR and p70S6K are shown in the lower panels. *p<0.05, **p<0.01, n = 5–6 per group for each experiment.