Table 1. Association results for the three new candidate CAD risk loci identified in stage 1, represented by the corresponding lead SNPs.
| rs9818870 |
rs7048915 |
rs2259816 |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of |
MAF (%) |
MAF (%) |
MAF (%) |
|||||||||||
| Cases | Controls | Cases | Controls | P value | OR (CI) | Cases | Controls | P value | OR (CI) | Cases | Controls | P value | OR (CI) | |
| Stage 1a | ||||||||||||||
| GerMIFS II |
1,222 | 1,298 | 19.5 | 15.0 | 2.38 × 10−5 | 1.37 (1.18,1.59) |
22.8 | 27.1 | 0.0004 | 0.79 (0.69,0.90) |
40.4 | 35.3 | 0.0002 | 1.25 (1.11,1.40) |
| Stage 2b | ||||||||||||||
| WTCCC | 1,926 | 2,938 | 17.0 | 15.1 | 0.0048 | 1.16 (1.05,1.27) |
21.6 | 23.4 | 0.0201 | 0.90 (0.82,0.98) |
36.3 | 34.3 | 0.0215 | 1.09 (1.02,1.17) |
| MIGen/ IATVB |
2,967 | 3,075 | 14.8 | 13.7 | 0.0390 | 1.10 (1.01,1.19) |
27.5 | 29.0 | 0.0302 | 0.93 (0.87,0.99) |
40.2 | 38.0 | 0.0066 | 1.10 (1.03,1.17) |
| GerMIFS I | 875 | 1,644 | 18.6 | 16.5 | 0.0427 | 1.15 (1.01,1.31) |
23.4 | 25.9 | 0.0185 | 0.87 (0.78,0.97) |
38.1 | 34.9 | 0.0118 | 1.15 (1.04,1.27) |
| Pooled | 5,768 | 7,657 | 16.1 | 14.8 | 0.0002 | 1.13 (1.07,1.19) |
25.0 | 26.3 | 0.0004 | 0.91 (0.87,0.95) |
38.6 | 35.9 | 5.89 × 10−5 | 1.10 (1.06,1.15) |
| Stage 3c | ||||||||||||||
| Population -based MIs |
2,737 | 4,469 | 17.4 | 15.0 | 0.0004 | 1.20 (1.10,1.31) |
26.0 | 27.2 | 0.1520 | 0.94 (0.85,1.04) |
37.5 | 35.4 | 0.0106 | 1.10 (1.03,1.17) |
| Hospital- based Mis |
772 | 734 | 18.9 | 13.5 | 2.85 × 10−5 | 1.52 (1.28,1.81) |
26.4 | 26.3 | 0.4879 | 1.00 (0.87,1.15) |
33.7 | 35.2 | 0.2002 | 0.94 (0.83,1.06) |
| Angio graphic CAD |
8,908 | 7,208 | 17.7 | 16.3 | 0.0008 | 1.10 (1.05,1.15) |
25.3 | 25.2 | 0.1915 | 1.02 (0.98,1.07) |
36.5 | 36.0 | 0.0410 | 1.04 (1.00,1.08) |
| Pooled | 12,417 | 12,411 | 17.7 | 15.9 | 2.69 × 10−7 | 1.14 (1.08,1.20) |
25.5 | 25.5 | 0.9999 | 1.01 (0.96,1.06) |
36.6 | 35.8 | 0.0277 | 1.05 (1.00,1.09) |
| All stagesd | 19,407 | 21,366 | 17.3 | 15.4 | 7.44 × 10−13 | 1.15 (1.11,1.19) |
25.1 | 25.9 | 0.0073 | 0.95 (0.92,0.99) |
37.4 | 35.8 | 4.81 × 10−7 | 1.08 (1.05,1.11) |
a
Stage 1: P value, odds ratio (OR), 95% confidence interval (95% CI) from two-sided trend test (CAT).
b
Stage 2: single study analysis: P value, OR, 90% CI from one-sided CAT; pooled analysis: P value, OR, 90% CI from one-sided Cochran-Mantel-Haenszel test (CMH).
c
Stage 3: population-based myocardial infarction studies: P value, OR, 90% CI from one-sided CMH (for rs7048915 only one study: one-sided CAT); hospital-based myocardial infarction studies: P value, OR, 90% CI from one-sided CAT; angiographic CAD studies: P value, OR, 90% CI from fixed-effect logistic regression models (FELRM) with adjustments for study and multiple testing.
d
All stages: P value, OR, 95% CI from (FELRM) with adjustments for study.