Table 1. Summary of Transporters Involved in Virulence or Toxin and Drug Efflux.
Transporter Family | Name | Fungus | Description/Substrate | Amino Acid Length | References |
ABC Transporters | |||||
PDR/ABCG | CDR1 | C. albicans | Triazole resistance | 1500 | [60],[72] |
PDR/ABCG | CDR2 | C. albicans | Triazole resistance | 1499 | [71]–[73] |
PDR/ABCG | CgCDR1 | C. glabrata | Fluconazole, itraconazole | 1542 | [59] |
PDR/ABCG | CgCDR2/PDH1 | C. glabrata | Fluconazole, ketoconazole | 1499 | [61],[85] |
PDR/ABCG | CgSNQ2 | C. glabrata | Fluconazole, itraconazole | 1507 | [62] |
PDR/ABCG | AFR1 | C. neoformans | Triazole resistance | 1543 | [58] |
PDR/ABCG | ABC1 | M. grisea | Unknown function | 1619 | [46] |
PDR/ABCG | GpABC1 | G. pulicaris | Rishitin tolerance | 1491 | [51] |
PDR/ABCG | Mgatr4 | M. graminicola | Unknown function | 1635 | [49] |
PDR/ABCG | BcatrB | B. cinerea | Resveratrol tolerance | 1439 | [48],[50] |
MRP/ABCC | MLT1 | C. albicans | Unknown function, possibly bile | 1606 | [55] |
MFS Transporters | |||||
DHA14 | TOXA | C. carbonum | HC-toxin secretion | 548 | [34] |
DHA14 | TRI12 | F. sporotrichioides | Trichothecene T-2 secretion | 598 | [40] |
DHA14 | CFP | C. kikuchii | Cercosporin secretion | 607 | [35] |
DHA12 | CTB4 | C. nicotianae | Cercosporin secretion | 512 | [36] |
DHA12 | cefT | A. chrysogenum | Cephalosporin secretion | 561 | [42] |
DHA14 | PEP5 | N. haematococca | Unknown function | 592 | [52] |
DHA12 | MDR1 | C. albicans | Fluconazole resistance | 564 | [76]–[78] |
DHA12 | FLU1 | C. albicans | Fluconazole resistance | 610 | [79] |
DHA12 | CdMDR1 | C. dubliniensis | Fluconazole resistance | 557 | [80],[81] |
DHA12 | TMP1 | C. albicans | MDR | 561 | [83] |
DHA12 | TMP2 | C. albicans | MDR | 581 | [83] |
Transporters involved in virulence are in bold.