Table 1. Lipid composition of mitochondria isolated from brain, brain tumour and cells.
Values are expressed as mean nmol/mg of protein±S.D. (n = 3). *P<0.05; **P<0.01 and ***P<0.001, significantly different values from B6 NS or astrocyte mitochondria. N.D., not detected.
| Lipid | In vivo | In vitro | ||||
| BrainC | CT-2A | EPEN | AstrocyteC | CT-2A | EPEN | |
| EtnGpl | 187.4±12.1 | 245.9±13.7** | 368.4±46.4* | 171.4±18.6 | 163.0±6.5 | 211.0±16.7 |
| PtdEtn | 164.9±10.0 | 137.3±6.0* | 259.4±45.7 | 85.9±3.4 | 69.7±3.0** | 98.9±2.3* |
| PlsEtn | 22.5±2.2 | 99.3±7.1** | 147.8±21.4** | 80.5±15.0 | 87.5±9.4 | 106.9±14.4 |
| PakEtn | N.D. | 9.3±0.7** | 12.4±3.0* | 5.0±0.3 | 5.7±0.1* | 5.1±1.1 |
| ChoGpl | 129.9±7.7 | 121.2±3.6 | 160.0±29.5 | 168.5±14.2 | 127.4±13.2* | 194.4±15.7 |
| PtdCho | 119.6±5.3 | 81.4±3.4** | 127.4±25.4 | 124.6±10.5 | 98.1±12.4* | 174.3±13.9** |
| PlsCho | 1.2±0.1 | 19.4±2.1*** | 11.6±4.8 | 22.4±4.0 | 15.8±0.8 | 9.3±0.8* |
| PakCho | 9.1±3.2 | 20.4±2.6** | 17.0±6.2 | 21.5±2.1 | 13.5±0.4* | 10.8±1.1** |
| Cardiolipin | 52.7±4.5 | 26.1±1.0** | 13.5±2.7*** | 28.3±4.3 | 24.6±3.7 | 31.1±4.2 |
| PtdIns | 9.4±0.8 | 9.5±2.6 | 19.4±2.5* | 18.5±2.4 | 18.4±1.6 | 20.5±3.3 |
| PtdGro | 7.1±0.5 | 9.8±0.5** | 16.4±3.6* | 7.7±2.6 | 7.6±1.5 | 4.7±0.3 |
| CerPCho | 5.3±1.2 | 4.6±0.2 | 5.8±1.8 | 9.7±1.4 | 15.9±3.4 | 22.1±1.3** |
| PtdSer | 4.6±1.5 | 9.1±0.6* | 10.4±2.0* | 17.8±0.4 | 28.7±5.7 | 24.1±3.6 |
| LysoPtdCho | 2.7±0.6 | 6.3±0.6** | 2.8±0.4 | 1.5±0.1 | 2.2±0.4 | 2.4±0.6 |
| Cer | 0.7±0.2 | 2.3±0.2*** | 1.7±0.2** | 0.9±0.1 | 1.0±0.5 | 2.0±0.2** |
CB6 NS brain mitochondria or astrocyte (C8-D1A) mitochondria were used as controls.