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Function of the FA pathway. Eight FA proteins form a nuclear complex, which acts as ubiquitin ligase. In response to DNA damage or replication stress, it monoubiquitinates two other FA proteins, FANCD2 and FANCI, which then recruit other downstream FA proteins FANCD1, FANCJ, and FANCN to damaged DNA and influence DNA replication, cell-cycle control, and DNA repair processes
