FIG. 5.

The effects of oxidative stress on HSC function. (A) Wild-type (WT) hematopoiesis, in which FA proteins regulate antioxidant response in HSC/P cells. The WT cells then recover from oxidative damage, survive, and proliferate normally. (B) Loss of FA function in HSC/P cells results in an increase in ROS, which ultimately results in increased accumulation of DNA damage and apoptotic death. (C) Reversal of this detrimental effect on HSC/P cells by administration of exogenous antioxidant, such as N-acetyl-L-cysteine (NAC) to the Fancc−/− mice, most likely due to the decrease in ROS