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Manipulation of p53 signaling alters H2O2-induced cell-cycle checkpoint in Fanca −/− bone marrow cells. Note that Fanca−/− cells expressing the p53 inhibitor (p53DD) evade from H2O2-induced G2/M arrest but suffer apoptosis; whereas forced activation of p53 by Nutlin-3a does not induce G2/M arrest in Fanca−/− cells with a functional p53, as evidenced by induction of G0/G1 arrest
