Table 1.

Model initial population characteristics

	I: Mild	II: Moderate	III: Severe	IV: Very severe	Total	Source
% population	42%	41%	13%	4%	100%	Price et al 2004
Initial population	1,216,444	1,187,481	376,518	115,852	2,896,296
FEV1 (% predicted)	89.80%	63.70%	40.00%	26.20%		Antonelli-Incalzi et al 2003
Exacerbations/patient/year	0	0.8	1.8	2.6		Authors’ estimate from ISOLDE (Hankinson et al 1999; Burge and Wedzicha 2003)