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. 2009 Apr 24;202(1):123–129. doi: 10.1677/JOE-09-0093

Figure 2.

Figure 2

Effect of pGlu-apelin-13 on plasma ACTH and CORT in wild-type (white bars) and V1bR KO mice (black bars). (A) Administration of pGlu-apelin-13 (1 mg/kg; 2 μl i.c.v.) resulted in a significant increase in plasma ACTH in wild-type but not in V1bR KO mice. (B) Administration of pGlu-apelin-13 (1 mg/kg; 2μl i.c.v.) resulted in a significant increase in plasma CORT in both wild-type and V1bR KO mice; however, the CORT response to pGlu-apelin-13 was significantly reduced in V1bR KO compared to wild-type mice. Data are expressed as mean±s.e.m. +++P<0·001, **P<0·01 two-way ANOVA using Bonferroni post hoc test.