Table 1.
The distribution, partners, and functions of vascular tetraspanins
| Tetraspanin | Cell type | Protein interactions | Specific functions |
|---|---|---|---|
| CD9 | Smooth muscle cells | α5β1 | Migration, proliferation, signalling |
| α2β1 | |||
| α3β1 | |||
| Endothelial cells | ICAM-1 | Transendothelial migration of leucocytes | |
| VCAM-1 | |||
| α3β1 | |||
| Platelets | GPIIb/IIIa | Aggregation, signalling | |
| GPIb/V/IX | |||
| CD151 | Smooth muscle cells | Not done | Not done |
| Endothelial cells | Tetraspanins such as CD9 and CD81 | Cell–ECM adhesion | |
| Integrins such as α3β1, α6β1, and α5β1 | Cell–cell adhesion | ||
| IgSF proteins such as ICAM-1 and VCAM-1 | Cell migration | ||
| MT1-MMP | Angiogenesis | ||
| Platelets | GPIIb/IIIa | Aggregation, spreading, adhesion to fibrinogen | |
| Tetraspanins such as CD9 | |||
| CD63 | Smooth muscle cells | Not done | Not done |
| Endothelial cells | vWF | Vesicle trafficking | |
| Platelets | GPIIb/IIIa | Spreading, signalling | |
| Type II PI-4K |