TABLE 4.
Evidence for the use of atypical antipsychotics in delirium
| STUDY MEDICATION | AUTHOR | N | STUDY DESIGN | RESULTS |
|---|---|---|---|---|
| Risperidone | Sipahimalani A, et al. | 2 | Case report | Risperidone safe and effective |
| Risperidone | Ravona-Springer, et al. | 3 | Case series | Risperidone thought to play a role in the etiology of delirium |
| Risperidone | Sipahimalani A, et al. | 11 | Case series | Risperidone safe and effective |
| Risperidone | Furmaga KM, et al. | 7 | Open trial | Risperidone safe and effective |
| Risperidone | Horikawa N, et al. | 10 | Open trial | Risperidone safe and effective |
| Risperidone | Mittal D, et al. | 10 | Open trial | Risperidone safe and effective |
| Risperidone | Parellada E, et al. | 64 | Open trial | Risperidone safe and effective |
| Risperidone | Hans CS, et al. | 12 vs. 12 | Double blind trial of risperidone vs. haloperidol | Risperidone equivalent to haloperidol |
| Risperidone | Naber D, et al. | 815 | Double blind placebo-controlled trial of risperidone | Risperidone not superior to placebo |
| Olanzapine | Passik SD, et al. | 1 | Case report | Olanzapine safe and effective |
| Olanzapine | Breitbart, et al. | 79 | Open trial | Olanzapine safe and effective |
| Olanzapine | Kim, et al. | 20 | Open trial | Olanzapine safe and effective |
| Olanzapine | Sipahimalani A, et al. | 11 vs. 11 | Open trial | Olanzapine equivalent to haloperidol |
| Olanzapine | Skrobik YK, et al. | 28 vs. 45 | Open trial | Olanzapine equivalent to haloperidol |
| Quetiapine | Torres R, et al. | 2 | Case report | Quetiapine safe and effective |
| Quetiapine | Al-Samarri S, et al. | 2 | Case report | Quetiapine safe and effective |
| Quetiapine | Schwartz TL, et al. | 11 vs. 11 | Retrospective chart review | Quetiapine equivalent to haloperidol |
| Quetiapine | Pae CU, et al. | 22 | Open trial | Quetiapine safe and effective |
| Quetiapine | Kim KY, et al. | 12 | Open trial | Quetiapine safe and effective |
| Quetiapine | Sasaki Y, et al. | 12 | Open trial | Quetiapine safe and effective |
| Quetiapine | Maneeton N, et al. | 17 | Open trial | Quetiapine safe and effective |
| Ziprasidone | Leso L, Schwartz TL | 1 | Case report | Ziprasidone effective but PVC’s limit use (medically ill, immunocompromised patient) |
| Ziprasidone | Young CC, Lugan E | 1 | Case report | Ziprasidone safe and effective |
| Aripiprazole | Alao AO, et al. | 2 | Case report | Aripiprazole safe and effective |
| Aripiprazole | Alao AO, Moskowitz L | 2 | Case report | Aripiprazole safe and effective |
| Aripiprazole | Straker DA, et al. | 14 | Case series | Aripiprazole safe and effective |