Table 2.

Analysis of the combination of two adjacent AS events

	First AS events			Second AS events
	Number of the AS eventsa	Frequencya		RI	AA	ES	AD
RI	509	0.45	Expectation valueb	156.5	82.1	58.1	54.4
			Observation value	221	71	12	25
			P-valuec	0.106	—	—	—
AA	267	0.23	Expectation valueb	82.1	43.1	30.5	28.6
			Observation value	60	42	11	21
			P-valuec	—	—	—	—
ES	189	0.17	Expectation valueb	58.1	30.5	21.6	20.2
			Observation value	14	59	85	13
			P-valuec	—	2.30E−05	<2.2E −16	—
AD	177	0.15	Expectation valueb	54.4	28.6	20.2	18.9
			Observation value	53	45	44	12
			P-valuec	—	0.009	1.32E−05	—

^aThese values were counted as novel AS variants with more than two AS events.

^bExpectation values. Calculated based on the frequencies of independent events. Case number is the observation number: 788.

^cResults of the binomial test. P-values are shown if the observation values are greater than the expectation values.