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. 2009 Jun 23;4(6):e6005. doi: 10.1371/journal.pone.0006005

Figure 5. Effect of co-injection of fibrin scaffold on hemodynamics of left ventricle under pharmacologic pressure stress.

Figure 5

Three days post-MI, animals were administered with medium intramuscular (M-IM), fibrin intramuscular (F-IM), BMC intravenous (BMC-IV), BMC intramuscular (BMC-IM), or BMC co-injected with fibrin intramuscular (BMC+F-IM) or animals were submitted to sham operation (Sham). (A) Change in stroke volume as a percentage change from baseline (mean±SE); * indicates statistical difference compared to all groups (M-IM, F-IM and BMC-IV: P<0.001, BMC: P<0.05 and BMC+F-IM: P<0.01), # indicates statistical difference compared to M-IM (P<0.001), F-IM (P<0.001) and BMC-IV (P<0.01) groups, & indicates statistical difference compared to M-IM (P<0.001), F-IM (P<0.001) and BMC-IV (P<0.05) groups. (B) Left ventricle end diastolic pressure (LVEDP) expressed in mmHg (mean±SE); * indicates statistical difference compared to M-IM, F-IM and BMC-IV groups for P<0.001, # indicates statistical difference compared to M-IM for P<0.001, F-IM (P<0.001) and BMC-IV (P<0.01) groups, & indicates statistical difference compared to M-IM for P<0.001, F-IM (P<0.001) and BMC-IV (P<0.05) groups, $ indicates statistical difference compared to M-IM (P<0.001) and F-IM (P<0.05). (C) * P<0.01 indicates statistically significant difference compared to M-IM group, # indicates statistically significant difference compared to M-IM for P<0.001 and BMC-IV (P<0.05) groups, & indicates statistical difference compared to M-IM group for P<0.001. (D) * indicates statistical difference compared to all groups (M-IM, F-IM and BMC-IV: P<0.001, BMC: P<0.05 and BMC+F-IM: P<0.01), # indicates statistical difference compared to M-IM (P<0.001), F-IM (P<0.001) and BMC-IV (P<0.01) groups, & indicates statistical difference compared to M-IM (P<0.001), F-IM (P<0.001) and BMC-IV (P<0.05) groups.