Table 1.
Gene signaling pathways and networks down-regulated in old mice.
Condition | Signaling Pathway (p value) |
Network Score |
Database | Functional annotations (p value) |
---|---|---|---|---|
60 min ischemia | Protein ubiqutination (3.8E-18) |
44 | D.A.V.I.D. | SP_PIR_KEYWORDS, proteasome (1.3E-31) |
|
||||
PANTHER |
Pathway: Ubiquitin proteasome pathway (8.6E-18) |
|||
Biological Process: Proteolysis (5.8E-13) |
||||
Molecular Function: Other proteases (1.4E-6) |
||||
| ||||
90 min ischemia | Protein ubiqutination (3.0E-12) |
50 | D.A.V.I.D. | INTERPRO_NAME, proteasome α subunit (1.3E-3) |
|
||||
PANTHER |
Pathway: Parkinsons disease (3.4E- 5) |
|||
Biological Process: Protein metabolism and modification (6.8E- 6) |
||||
Molecular Function: Chaperonin (5.7E-6) |
||||
|
||||
45 | D.A.V.I.D. | SP_PIR_KEYWORDS, proteasome (2.2E-15) |
||
|
||||
PANTHER |
Pathway: Ubiquitin proteasome pathway (1.2E-9) |
|||
Biological Process: Proteolysis (1.3E-4) |
||||
Molecular Function: Nucleic acid binding (1.0E-2) |
||||
| ||||
90 min ischemia + 1 h reperfusion |
Protein ubiqutination (3.4E-9) |
38 | D.A.V.I.D. | SP_PIR_KEYWORDS, proteasome (4.3E-18) |
|
||||
PANTHER |
Pathway: Ubiquitin proteasome pathway (2.0E-9) |
|||
Biological Process: Protein metabolism and modification (9.7E- 8) |
||||
Molecular Function: Other proteases (7.4E-3) |