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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Hepatology. 2009 May;49(5):1718–1728. doi: 10.1002/hep.22840

Table 1.

Gene signaling pathways and networks down-regulated in old mice.

Condition Signaling Pathway
(p value)
Network
Score
Database Functional annotations (p value)
60 min ischemia Protein ubiqutination
(3.8E-18)
44 D.A.V.I.D. SP_PIR_KEYWORDS, proteasome
(1.3E-31)

PANTHER Pathway: Ubiquitin proteasome
pathway (8.6E-18)
Biological Process: Proteolysis
(5.8E-13)
Molecular Function: Other
proteases (1.4E-6)

90 min ischemia Protein ubiqutination
(3.0E-12)
50 D.A.V.I.D. INTERPRO_NAME, proteasome α
subunit (1.3E-3)

PANTHER Pathway: Parkinsons disease (3.4E-
5)
Biological Process: Protein
metabolism and modification (6.8E-
6)
Molecular Function: Chaperonin
(5.7E-6)

45 D.A.V.I.D. SP_PIR_KEYWORDS, proteasome
(2.2E-15)

PANTHER Pathway: Ubiquitin proteasome
pathway (1.2E-9)
Biological Process: Proteolysis
(1.3E-4)
Molecular Function: Nucleic acid
binding (1.0E-2)

90 min ischemia +
1 h reperfusion
Protein ubiqutination
(3.4E-9)
38 D.A.V.I.D. SP_PIR_KEYWORDS, proteasome
(4.3E-18)

PANTHER Pathway: Ubiquitin proteasome
pathway (2.0E-9)
Biological Process: Protein
metabolism and modification (9.7E-
8)
Molecular Function: Other
proteases (7.4E-3)
HHS Vulnerability Disclosure