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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Hepatology. 2008 Oct;48(4):1213–1223. doi: 10.1002/hep.22471

Figure 5.

Figure 5

Effects of SB225002 on hepatic ischemia/reperfusion injury. Mice were injected intra-peritoneally with 3% dimethylsulfoxide solution (control) or 4 mg/kg SB225002 after 24 hours of reperfusion and every 24 hours thereafter. (A) Neutrophil accumulation was determined by liver content of MPO. Data are mean ± SEM with n=4 per group. (B) Liver injury was measured by serum levels of ALT. Data are mean ± SEM with n=4-6 per group. *P<0.05 compared with control. (C) Liver histology. Sham-operated mice displayed normal hepatic architecture. After 48 hours of reperfusion, livers from control mice had large areas of necrosis. Livers from mice treated with SB225002 had less necrosis. After 96 hours of reperfusion, livers from control mice had large areas of necrosis. However livers from mice treated with SB225002 had far fewer and smaller necrotic areas. Asterisks indicate necrotic areas. Original magnification was 50X.