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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Hepatology. 2008 Oct;48(4):1213–1223. doi: 10.1002/hep.22471

Figure 6.

Figure 6

Effects of SB225002 on hepatocyte proliferation after ischemia/reperfusion injury. (A) Hepatocyte proliferation was determined by immunohistochemical staining for proliferating cell nuclear antigen (PCNA). Mice were injected intra-peritoneally with 3% dimethylsulfoxide solution (control) or 4 mg/kg SB225002 after 24 hours of reperfusion and every 24 hours thereafter. Livers from sham-operated mice had almost no PCNA-positive hepatocytes. After 48 hours of reperfusion, PCNA staining was similar between control and SB225002-treated mice. After 96 hours of reperfusion, there were increased numbers of PCNA-positive hepatocytes in livers from control mice. However, there were far more PCNA-positive hepatocytes in SB225002-treated mice. Original magnification was 400X. (B) Quantitative analysis of PCNA labeling. Data are mean ± SEM with n=4 per group. *P<0.05 compared with control mice.