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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Hepatology. 2008 Oct;48(4):1213–1223. doi: 10.1002/hep.22471

Figure 7.

Figure 7

Effects of SB225002 on liver activation of (A) NF-κB and (B) STAT3 after ischemia/reperfusion. Mice were injected intra-peritoneally with 3% dimethylsulfoxide solution (control) or 4 mg/kg SB225002 after 24 hours of reperfusion and every 24 hours thereafter. For NF-κB, nuclear extracts were analyzed by EMSA. Liver nuclear extracts from mice undergoing sham surgery were subjected to competition assay with cold NF-κB or CREB oligonucleotides. For STAT3, phosphorylated STAT3 was detected by Western blot with β-actin staining as a control. Results were quantitated by image analysis of autoradiograms. Data are mean ± SEM with n=3-6 per group. *P<0.05 compared with wild-type mice.