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Effects of CXCR2 signaling hepatocyte cell death. Primary mouse hepatocytes from wild-type (A) and CXCR2-/- (B) mice were treated with MIP-2 (0-10,000 ng/ml) for 24 hours. Cell death was determined by release of LDH. (C) Active caspase-3 levels after MIP-2 treatment (0, 10, 10,000 ng/ml) were measured by ELISA. Data are mean ± SEM with n=7-22 replicates per group. *P<0.05 compared with 0 ng/ml.
