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. Author manuscript; available in PMC: 2009 Dec 18.
Published in final edited form as: J Control Release. 2008 Jul 18;132(3):193–199. doi: 10.1016/j.jconrel.2008.07.014

FIGURE 4.

FIGURE 4

Biodistribution of 111In-labeled HPMA copolymer-RGDfK conjugates with increased electronegative charge and varying Mw: (A) 43 kD, (B) 20 kD and (C) 10 kD. Activity per organ is expressed as % injected dose per gram of tissue (%ID/g) following necropsy at 15 min, 1, 6, 24, 48, 96, 192 and 240 h post-intravenous injection. Data confirms image analysis showing rapid loss of activity from blood, highest accumulation in kidney and no sustained tumor activity. Data is expressed as mean ±SD (number of mice/group is shown.