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Cumulative urinary excretion of radiolabeled copolymer conjugates. Data represents radioactivity measured in urine represented as percent injected dose recovered from groups of 4 mice per treatment injected with 111In-labeled HPMA copolymer-RGDfK conjugates of varying Mw: 43 kD (▲), 20 kD (■) and 10 kD (♦). For each Mw, the largest percentage of dose was recovered in urine within 24 h. As copolymer Mw increases, a decrease in urinary excretion is observed.
