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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Cell Metab. 2009 May;9(5):474–481. doi: 10.1016/j.cmet.2009.03.003

Figure 4. Reduction in Aortic Root Lesion Area, Necrotic Area, and Apoptosis in Ldlr−/−;Chop−/− Mice.

Figure 4

(A) Body weight, plasma total cholesterol, plasma HDL cholesterol, and FPLC plasma cholesterol profile of 12-wk Western diet-fed male Chop+/+;Ldlr−/− and Chop−/−;Ldlr−/− mice (n = 12 and 17, respectively). None of the differences between the two groups of mice in these parameters were statistically significant.

(B), Quantification of total aortic root lesion area and necrotic area of the mice described in A. *, P<0.05.

(C) Representative micrographs and quantification of TUNEL-positive signal (red) in nuclei (blue) of aortic root lesions from Chop−/−;Ldlr−/− lesions. Bar, 10 μm. *, P<0.05.

(D) Quantification of activated caspase-3 in aortic root lesions from Chop+/+;Ldlr−/− and Chop−/−;Ldlr−/ lesions. *, P<0.05.