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. Author manuscript; available in PMC: 2009 Jun 13.
Published in final edited form as: Br J Nutr. 2008 Nov 5;101(11):1630–1638. doi: 10.1017/S0007114508118785

Table 3. Changes in gene expression in perirenal adipose as a result of feeding either a chow or a high fat, high cholesterol diet supplemented with 0.25% (wt/wt) CLA isomers (n=8 animals per group). Data are expressed in arbitrary unit relative to β-actin mRNA.

CLA ANOVA1
None c9,t11 t10,c12 mean SED P value
ACC Chow
HF/HC
mean 		1.70
0.81
1.25		 1.43
0.62
1.05		 1.87
0.58
1.23		 1.67
0.69
1.18		 D
C
D×C		 0.16
0.19
0.27		 <0.001
0.533
0.371
FAS Chow
HF/HC
mean 		1.79
0.72
1.25		 1.93
0.83
1.38		 1.55
0.45
1.00		 1.76
0.66
1.21		 D
C
D×C		 0.18
0.22
0.31		 0.001
0.227
0.995
LPL Chow
HF/HC
mean 		1.78
1.00
1.39a 		1.51
1.14
1.32a 		0.96
0.53
0.74b 		1.41
0.89
1.15		 D
C
D×C		 0.14
0.17
0.24		 <0.001
<0.001
0.427
SREBP-1a Chow
HF/HC
mean 		1.63
0.88
1.26		 1.25
1.23
1.24		 1.43
0.69
1.06		 1.44
0.94
1.19		 D
C
D×C		 0.14
0.17
0.24		 <0.001
0.429
0.056
SREBP-1c Chow
HF/HC
mean 		1.66
1.14
1.40a 		1.55
1.32
1.44a 		1.27
0.64
0.96b 		1.49
1.03
1.26		 D
C
D×C		 0.14
0.18
0.25		 0.003
0.018
0.513
SREBP-2 Chow
HF/HC
mean 		1.44
0.97
1.21		 1.27
0.77
1.02		 1.19
0.50
0.84		 1.30
0.75
1.02		 D
C
D×C		 0.15
0.18
0.26		 <0.001
0.154
0.803
1

Statistical values were obtained by two-way ANOVA with background diet (D, chow or HF/HC) as one factor and CLA (C, none, c9,t11 or t10,c12) as a second factor. SED: standard error of the difference