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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1953–1962. doi: 10.1021/jm801514w

Figure 1.

Figure 1

Predicted score (tPS) plots illustrating the difference in coverage of biologically relevant chemical space by natural products (NPs, in green) and bioactive medicinal chemistry compounds from the database WOMBAT (in black) in the first three principal components. NPs cover parts of chemical space that lack representation in medicinal chemistry compounds, indicating that these areas have yet to be investigated in drug discovery. They appear to contain lead-like NPs that could subsequently be of interest in drug discovery.