Table 1.
Hemodynamic parameters in patients with cardiac sympathetic denervation (DEN), normal cardiac innervation (INN) and healthy controls (CON) at baseline and during i.v. infusion of tyramine (TYR).
DEN (n=13) | INN (n=15) | CON (n=5) | ||||
---|---|---|---|---|---|---|
Baseline | TYR | Baseline | TYR | Baseline | TYR | |
HR (bpm) | 68.8±3.3 | 70±4.1 | 73.5±2.6 | 71.2±3.2 | 61±5 | 55±3.9 |
SV (mL) | 76.2±5.6 | 82.6±6.0 | 78.3±4.3 | 87.8±3.3 | 82.2±9.2 | 98±11.2 |
CO (L/min) | 5.14±0.4 | 5.65±0.4 | 5.70±0.3 | 6.23±0.4 | 4.87±0.36 | 5.3±0.55 |
PEP (ms) | 104±6.9 | 94±7.9* | 99.4±6.9 | 71.8±5.8† | 113±3.5 | 86±6.6 |
LVET (ms) | 316±7.0 | 324±5.6 | 300±6.4 | 317±7.5 | 314±10 | 349±18 |
LVETI (ms) | 433±8.7 | 4436.9 | 431±7.3 | 443±8.7 | 417±3 | 442±14 |
VI (cm/s) | 35.9±3.2 | 40.0±3.5 | 32.9±1.9 | 41.0±3.6 | 35.4±4.8 | 40±5.5 |
ACI (cm/s) | 61.4±6.4 | 70.4±7.6 | 56.3±5.6 | 68.1±7.6 | 61±11 | 77.2±12 |
BRG (ms/mm Hg) | 0.86±0.1 | - | 1.51±0.5 | - | 6.1±1.2 | - |
p<0.05, DEN vs. INN
p<0.05, DEN vs. INN for change from baseline
Abbreviations: heart rate (HR), stroke volume (SV), cardiac output (CO), preejection period (PEP), left ventricular ejection time (LVET), left ventricular ejection time index (LVETI), velocity index (VI), acceleration index (ACI), baroreflex gain (BRG)