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. 2009 May 13;48(7):734–740. doi: 10.1093/rheumatology/kep091

Fig. 4.

Fig. 4.

The expression of VCAM-1 and ICAM-1 on SSc dermal fibroblasts is highly inducible. Cell surface ELISAs were performed to determine if VCAM-1 and ICAM-1 expression on the surface of SSc dermal fibroblasts was inducible by cytokine stimulation. (A) VCAM-1 expression on SSc dermal fibroblasts was induced by TNF-α (25 ng/ml) stimulation. (B) TNF-α-induced VCAM-1 expression on SSc dermal fibroblasts in a dose-dependent manner. (C) ICAM-1 expression on SSc dermal fibroblasts was induced by TNF-α, IFN-γ, IL-1β, IL-17, but not IL-18 (each 25 ng/ml). (D) IL-17-induced ICAM-1 expression on SSc dermal fibroblasts in a dose-dependent manner. Means ± SEM are shown. n = number of patient-derived fibroblast lines.