Fig. 1.

The development of spontaneous seizures in kainate-treated rats. Rats were treated with kainate (12mg/kg; s.c) to initiate SE and seizures scored as described in Materials and Methods. Behavioral observations of seizure activity were monitored for 6hr a week and rats that suffered ≥ 2 spontaneous seizures were considered to be epileptic. Saline treated controls did not show any seizure activity or modulation of oxidative stress indices throughout the study. For each animal A) the most severe motor seizure score and B) length of each seizure was determined at the indicated time point after kainate administration. Bars represent mean ± SEM, n=3–4 per time point.