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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Neurobiol Dis. 2008 Jan 5;30(1):130–138. doi: 10.1016/j.nbd.2007.12.009

Fig. 3.

Fig. 3

A comparison of mitochondrial and nuclear DNA damage during epileptogenesis. Hippocampal tissue was harvested at the indicated time points, DNA extracted and QPCR performed. The graph represents the number of DNA lesions per 10kb in a mitochondrial or nuclear gene fragment. Data was normalized to 250bp fragments amplified from saline treated controls. A) mtDNA and nDNA lesions per 10kb at the indicated time points after kainate treatment. B and C) Agarose gels derived from QPCR analysis of hippocampal tissue after kainate treatment. Lane 1, CON; lane 2, 24h; lane 3; Lane 4, 48h; Lane 5, 96h; Lane 6, 7d; Lane 7, 21d; Lane 8, 3m. Bars represent mean ± SEM. *P<0.05; **P<0.01, vs. saline treated controls; #P<0.05 mtDNA vs. nDNA, one way ANOVA, n= 6 per group.

HHS Vulnerability Disclosure