Table 1.
Receptor | GABA EC50 (μM) | GABA Hill coefficient |
---|---|---|
α1β2 | 1.6 ± 0.2 | 1.3 ± 0.1 |
α1(T6′F) β2 | 1.7 ± 0.3 | 0.9 ± 0.1 |
α1β2(T6′F) | 3.6 ± 0.5* | 1.1 ± 0.1 |
α1(T6′F) β2(T6′F) | ND | ND |
α1β2γ2 | 19.5 ± 1.8 | 1.3 ± 0.1 |
α1(T6′F)β2γ2 | 39.5 ± 1.1* | 1.2 ± 0.03 |
α1β2(T6′F)γ2 | 9.4 ± 0.4 | 1.4 ± 0.1 |
α1β2γ2(T6′F) | 9.4 ± 1.4 | 0.8 ± 0.1 |
α1(T6′F)β2γ2(T6′F) | 16.7 ± 2.0 | 0.9 ± 0.1 |
α1(T6′F)β2(T6′F)γ2 | 12.4 ± 0.8 | 0.58 ± 0.03* |
α1(T6′F)β2(T6′F)γ2(T6′F) | ND | ND |
denotes significantly different (p < 0.05, unpaired t-test) from wild type receptor. N = a minimum of four cells for all receptor configurations. ND, not determined due to inability to detect GABA-gated currents.