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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Neurosci Lett. 2007 Dec 3;431(2):184–189. doi: 10.1016/j.neulet.2007.11.039

Table 1.

GABA sensitivity in α1β2 and α1β2γ2 GABAA receptors carrying the T6′F mutant in one or more subunits.

Receptor GABA EC50 (μM) GABA Hill coefficient
α1β2 1.6 ± 0.2 1.3 ± 0.1
α1(T6′F) β2 1.7 ± 0.3 0.9 ± 0.1
α1β2(T6′F) 3.6 ± 0.5* 1.1 ± 0.1
α1(T6′F) β2(T6′F) ND ND
α1β2γ2 19.5 ± 1.8 1.3 ± 0.1
α1(T6′F)β2γ2 39.5 ± 1.1* 1.2 ± 0.03
α1β2(T6′F)γ2 9.4 ± 0.4 1.4 ± 0.1
α1β2γ2(T6′F) 9.4 ± 1.4 0.8 ± 0.1
α1(T6′F)β2γ2(T6′F) 16.7 ± 2.0 0.9 ± 0.1
α1(T6′F)β2(T6′F)γ2 12.4 ± 0.8 0.58 ± 0.03*
α1(T6′F)β2(T6′F)γ2(T6′F) ND ND
*

denotes significantly different (p < 0.05, unpaired t-test) from wild type receptor. N = a minimum of four cells for all receptor configurations. ND, not determined due to inability to detect GABA-gated currents.