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Formation of protein mixed disulfide. Both glutathione peroxidases and peroxiredoxin 6 can catalyze the oxidation of glutathione by hydrogen peroxide to glutathione disulfide and water. GSSG can then undergo an exchange reaction with protein sulfhydryl to form PSSG, which is usually catalyzed by a protein disulfide isomerase. An alternative mechanism is the oxidation of a protein thiolate to a sulfenic acid, which then will react with GSH to form PSSG and water.
