Figure 7. Effect of preventive treatment with histamine receptor agonists and antagonists on the occurrence of cerebral malaria.

Wild-type C57BL/6 and H3R^−/− mice were left untreated (diamonds) or treated (squares) with a H3R agonist R-α-MeHA or either the H1R or H2R inhibitors, respectively, Levocetirizine, and Cimetidine, before and during infection with 10⁶ infected erythrocytes per mouse. These data are from two independent experiments. Significant differences in mortality/survival (A, B, C, D, E) were observed between drug-treated and untreated mice using the log-rank test. No significant differences in parasitemia between treated and untreated groups (F, G, H, I, J) were observed.