Table 1. Amplitude of VEP normalized after CCh injection or HDB stimulation and drug treatment.
| Amplitude (%) | 0 min | 30 min | 60 min | 90 min | 120 min | 150 min | 180 min | 210 min |
| Cholinergic enhancement | ||||||||
| Control | 100 | 99±11 | 86±19 | 91±17 | 83±29 | 84±15 | 94±12 | 92±11 |
| Carbachol (CCh) | 100 | 101±11 | 127±39* | 151±41* | 142±32* | 144±12* | 156±21* | 149±16* |
| HDB stimulation | 100 | 95±04 | 154±03* | 144±03* | 140±21* | 159±02* | 126±19* | 147±22* |
| Sco (i.p.)+CCh | 100 | 90±14 | 54±02* | 89±14 | 78±15 | 86±19 | 95±18 | 114±08 |
| CCh+Sco (i.p.) | 100 | 95±08 | 130±45* | 182±40* | 165±17* | 148±24* | 162±04* | 153±25* |
| Pharmacological treatment | ||||||||
| aCSF+CCh | 100 | 95±15 | 105±13 | 92±12 | 115±18 | 122±14 | 130±18 | 112±13 |
| Sco (i.c.)+CCh | 100 | 78±26 | 108±34 | 93±24 | 64±05# | 72±16# | 84±29# | 85±22# |
| Mec+CCh | 100 | 99±10 | 115±10 | 101±10 | 77±21# | 97±08# | 90±09# | 91±11# |
| MLA+CCh | 100 | 102±06 | 94±07 | 83±15 | 152±29# | 100±22# | 86±06# | 131±08# |
| CPP+CCh | 100 | 106±22 | 91±08 | 111±16 | 88±14# | 108±18 | 100±12# | 81±15# |
Values are expressed in mean±SD. For the first set of experiment (cholinergic enhancement) CCh infusion and HDB stimulation were administrated at t = 60 min. For pharmacological treatment, antagonists were injected at t = 60 min followed by CCh at t = 120 min.
*
p<0.05, compared to control, ANOVA and LSD post-hoc.
#
p<0.05, compared to aCSF+CCh, ANOVA and LSD post-hoc.