Table 1.
Sequences of the H3s of antibody clones selected by panning against gp140R2. The antibody DNA was sequenced and the amino acid sequences of the complementarity determining region 3 (H3) were determined by using the GCG program. The differences of each clone are highlighted in comparison to the previously identified antibodies m14 and m18.
| gp140R2 Clones | H3 | Sequence Similarity | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R-1(m22) | A | R | Y | H | R | H | F | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-2 (m24) | A | R | E | R | R | V | L | R | W | L | G | F | P | R | G | G | L | D | Y | m14 |
| R-3 | A | R | Y | Y | R | H | V | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-4 | A | R | Y | H | R | H | F | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-5 | A | R | Y | Y | R | H | V | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-6 | A | R | Y | Y | R | H | V | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-7 | A | R | Y | Y | R | H | V | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-8 | A | R | Y | N | R | H | M | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-9 | A | R | Y | H | R | H | F | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-10 | A | R | Y | Y | R | H | V | I | R | G | P | L | S | F | D | Y | m18 | |||
| R-11 | A | R | E | R | R | V | L | L | W | L | G | F | P | R | G | G | L | D | Y | m14 |
| R-12 | A | R | L | K | L | R | G | A | F | D | F | Unique | ||||||||
| R-13 | A | R | L | K | L | R | G | A | F | D | F | Unique | ||||||||
| R-14 | A | R | A | E | R | V | L | F | W | L | G | Q | P | R | G | G | L | D | P | Unique |