. Author manuscript; available in PMC: 2009 Jun 15.

Published in final edited form as: Virology. 2007 Feb 15;363(1):79–90. doi: 10.1016/j.virol.2007.01.015

Table 6.

Comparison of neutralization of HIV-1 primary isolates from different clades by IgG m46 and T20 measured by a pseudovirus-based assay using cell lines with different CCR5 surface concentrations.

Various concentrations of IgG m46 and T20 were mixed with viruses pseudotyped with the Env from different clades of HIV-1 for 30 minutes at 37°C and mixed with cells expressing high or low CCR5 concentrations in triplicate wells. The IC₅₀ (in nM) was calculated as described in Table 5.

HIV-1 Clade	Antibody	High CCR5	Low CCR5
	IgG m46	>334 (41%)	214
92UG037.8 (Clade A)	T20	445	111

	IgG m46	247	80
Bal (Clade B)	T20	89	8.9

	IgG m46	>334 (32 %)	147
GXC-44 (Clade C)	T20	668	89

	IgG m46	80	30
Z2Z6 (Clade D)	T20	734	111

	IgG m46	214	67
CM243 (Clade E)	T20	45	8.9