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. Author manuscript; available in PMC: 2009 Jul 28.
Published in final edited form as: Nature. 2008 Dec 10;457(7229):599–602. doi: 10.1038/nature07586

Figure 1. GNAQQ209L transforms melanocytes.

Figure 1

a, GNAQQ209L induces anchorage independent growth in soft agar of hTERT/CDK4R24C/p53DD melanocytes in a TPA-independent manner with comparable efficiency as NRASQ61R. b, Cells expressing Flag-tagged GNAQQ209L showed enlarged nuclei with irregular contours after 5 days. c, Melan-a cells23 stably transduced with GNAQQ209L, but not with wild-type GNAQ (n=3) or vector control (n=4), induce highly pigmented tumors of spindled and epithelioid melanocytes after 10 weeks in four out of five animals.