Fig. 7.

Rsl-dependent liver gene regulation. Examples of targets that are likely regulated by direct repression include Slp, Sult3a1, Fmo3, and Cyp3a41. Genes such as Ugt2b38, Thrsp, and Angptl4 had expression patterns similar to Slp (i.e., higher in rsl than wt mice) but were only partially restored to wt levels by Rsl overexpression. Unexpected was the large proportion of genes that had the inverse expression pattern (i.e., lower in rsl than wt mice and elevated by Rsl overexpression) (e.g., Elovl3, Asns, Hsd3b5, etc.). Together these latter groups are likely controlled by indirect regulation via activators or repressors in pathways downstream from Rsl repression.