Table 4.
GO terms enriched within Rsl-regulated genes
| GO Term | Overall P Value | Overlap Gene Counta | Male P Value | Overlap Gene Countb | Set Gene Countc |
|---|---|---|---|---|---|
| Steroid biosynthetic process | 2.75E-06 | 18 | 2.86E-07 | 16 | 62 |
| Sterol biosynthetic process | 3.36E-06 | 12 | 4.67E-07 | 11 | 27 |
| Steroid metabolic process | 2.86E-05 | 20 | 1.55E-04 | 17 | 121 |
| Cholesterol biosynthetic process | 2.86E-05 | 10 | 9.06E-06 | 9 | 22 |
| Sterol metabolic process | 1.63E-04 | 15 | 3.85E-05 | 13 | 62 |
| Alcohol metabolic process | 2.16E-04 | 29 | 5.50E-05 | 24 | 232 |
| Vesicular fraction | 0.00103 | 19 | 0.023 | 14 | 132 |
| Cholesterol metabolic process | 0.00133 | 13 | 5.90E-04 | 11 | 57 |
| Lipid biosynthetic process | 0.00141 | 26 | 1.87E-05 | 22 | 214 |
| Microsome | 0.0146 | 17 | 0.099 | 12 | 128 |
| Regulation of catalytic activity | 0.0489 | 28 | >0.1 | 276 | |
| Cellular lipid metabolic process | 0.00126 | 33 | 457 | ||
| Lipid metabolic process | 0.00364 | 36 | 536 | ||
| Pyrimidine base metabolic process | 0.023 | 4 | 9 |
Out of 1,528 microarray spots, 1,491 correspond to unique genes and 732 had annotated Gene Ontology (GO) terms. The 732 genes were analyzed for GO term enrichment against the GO database consisting of 14,331 genes. P values were calculated to identify enrichment (P < 0.05) and the false discovery rate was controlled by the method of Benjamini. P values in italics are greater than the cutoff for significance of 0.05.
The number of genes within the 732 annotated, Rsl-regulated genes that are annotated with the given category.
The number of genes within the 481 annotated, Rsl-regulated genes in males that are annotated with the given category.
The number of genes within all 14,331 annotated genes in the GOstat database that are annotated with the given category.