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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Nat Neurosci. 2009 Mar 15;12(4):387–389. doi: 10.1038/nn.2290

Fig. 3. JNK promotes Wallerian degeneration and is critical in the first three hours after axotomy.

Fig. 3

Wildtype DRG axons distal to the axotomy twenty-four hours post-axotomy. (a) Shaded areas designate the drug treatment period. ↓P38 refers to the P38 inhibitor (SB203580, 20 μM) and ↓JNK refers to the JNK inhibitor (SP600125, 15 μM). (b) DI of conditions c–h. (c–h) Phase contrast images of axotomized wildtype DRG axons with the indicated drug treatment. Conditions e and g are significantly less degenerated than c, d, f, and h (p< 0.001, ANOVA and post-hoc Tukey test). Error bars are s.e.m. Scale bar = 20 μm.