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Synthetic outline for the preparation of Class E analogs.
Reagents and conditions: (I) ω-Br-acyl chlorides, DIPEA, THF, rt; (ii) 2M ammonium in ethanol, 1.5 N NaOH, rt; (iii) methylamine, 33% in absolute ethanol, 1.5N NaOH, rt; (iv) 2M N,N-dimethylamine in THF, 1.5N NaOH, rt; (v) octylamine, THF, 1.5N NaOH, rt; (vi) imidazol, THF, 1.5 N NaOH, rt; (vii) morpholine, THF, 1.5N NaOH, rt.
