Fig. 1.

Nelfinavir (NFV) stabilizes mitochondrial membrane potential in acinar cells. Acini were preincubated with saline (CON) or 30 micromolar NFV for 30 min (solid bars) followed by addition of 10 nM caerulein (Cer) for 3 h as indicated. 3, 3′-Dihexyloxacarbocyanine (DiOC6) retention was measured as described in materials and methods and expressed as means ± SE from 3 different experiments. *P value <0.05 compared with vehicle-treated group. There was no difference induced by vehicle treatment compared with caerulein alone.