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SP increases the expression of molecules that are involved in cell cycle progression. SP increases the efficiency of protein translation. Serum-starved human mesenteric preadipocytes were exposed to SP (10−7 M) or SP + CJ 012,255 for the indicated times. Cells were lysed, and equal amounts of protein were fractionated by SDS/12.5% PAGE to determine levels of phospho-4E binding protein 1 (4E-BP1) (A), phospho-p70 S6 kinase (B), and GAPDH.
