Figure 5.
Cardiac hypertrophy in PD168 rats (a) absolute heart weight and (b) heart-to-body-weight ratio in normal male SD rats chronically treated with PD168 at the dose of 10 mg/kg·body weight (PD-10) or 50 mg/kg·body weight (PD-50) relative to vehicle (VEH), (n = 10/treatment group). Means were compared using one-way ANOVA followed by Holm-Sidak test. Data are represented as means ± SEM. Different letters represent significant differences between the groups with “A” being highest mean and so forth (p < 0.05 was considered significant).