Figure 6.

Left ventricular expansion and ejection fraction in PD168 treated rats. (a) Left ventricular area (LVA) in systole and diastole; (b) Left ventricular internal dimension (LVID) in systole and diastole in normal male SD rats chronically treated with vehicle (VEH), PD168 at the dose of 10 mg/kg·body weight (PD-10) or 50 mg/kg·body weight (PD-50), (n = 10/treatment group). Means were compared using one-way ANOVA followed by Holm-Sidak test. Data are represented as means ± SEM. Different letters represent significant differences between the groups with “A” being highest mean and “AB” not different from “A” or “B” and so forth (p < 0.05 was considered significant).