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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Neuron. 2008 Feb 28;57(4):559–570. doi: 10.1016/j.neuron.2007.12.029

Figure 4.

Figure 4

Forskolin potentiates both the current and rise in dendritic calcium induced by the activation of metabotropic glutamate and muscarinic receptors. A (left) raw current traces showing the aspartate (L-Asp)-induced current potentiated by forskolin (3 µM). Right side, summarized results showing individual experiments (lines) and the averaged results (bars) in control and during forskolin. B left side, raw trace of the aspartate-induced increase in fluorescence (Δ G/R) and the facilitation caused by forskolin. Right side, summarized results showing individual (lines) and averaged data (bars) indicated the facilitation in calcium release induced by forskolin. The fluorescencent indicators tested included OGB488-5N (-Δ-), Fluo-5 (-□-) and Fluo-4 (-○-). The summarized data from A and B are from the same cells. C and D show results using the iontophoretic application of acetylcholine (ACh) in the presence of hexamethonium to activate muscarinic acetylcholine receptors, using the same protocol as described in A and B. Statistical significance is signified by * p < 0.05 and *** p < 0.001.