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Model for the functional relationship of proteasomal degradation and autophagy in removing misfolded proteins from the ER. 1) The folding states of newly synthesized proteins are monitored by the ER quality-control machineries. 2) Misfolded proteins are initially subjected to proteasomal degradation. 3) Misfolded proteins form ER-associated complexes (ERACs). 4) ERACs are delivered for autophagic degradation.
