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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Biochim Biophys Acta. 2006 Oct 7;1773(8):1263–1284. doi: 10.1016/j.bbamcr.2006.10.001

Figure 1. Overview of Raf/MEK/ERK Pathway.

Figure 1

The Raf/MEK/ERK pathway is regulated by Ras as well as various kinases, which serve to phosphorylate S/T and Y residues on Raf. Some of these phosphorylation events serve to enhance Raf activity (shown by a black P in a white circle) whereas others serve to inhibit Raf activity (shown by a white P in a black circle. Moreover there are phosphatases such as PP2A, which remove phosphates on certain regulatory residues. The downstream transcription factors regulated by this pathway are indicated in diamond shaped outlines.