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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Biochim Biophys Acta. 2006 Oct 7;1773(8):1263–1284. doi: 10.1016/j.bbamcr.2006.10.001

Figure 7. Sites of Action of Small Molecular Weight Signal Transduction Pathway Inhibitors.

Figure 7

Potential sites of action of small molecular weight inhibitors are indicated. In some cases inhibitors will suppress growth, apoptotic and cell cycle regulatory pathways. This diagram serves to illustrate the concept that targeting Raf/MEK/ERK and PI3K/Akt can have dramatic effects on many growth regulatory molecules. Proteins inactivated by S/T phosphorylation induced by the PI3K/Akt pathway are shown in black circles with white P in a black circle.